Nancy McNamara
OD, OD - Doctor of Optometry PhD PhD - Doctor of Philosophy

Title

Professor and Associate Dean for Student Affairs

Nancy McNamara
OD, OD - Doctor of Optometry PhD PhD - Doctor of Philosophy

Title

Professor and Associate Dean for Student Affairs

Additional Job Duties

Co-Chief, Dry Eye Clinic
UCB Associate Professor

Publications

Articles

Rutar T, Youm J, Porco T, Tilton N, Muskat M, McNamara N, Wara D. Ophthalmic manifestations of perinatally acquired HIV in a US cohort of long-term survivors. Br J Ophthalmol. 2015 May; 99(5):650-3. PMID: 25416182

Rose-Nussbaumer J, Lietman TM, Shiboski CH, Shiboski SC, Bunya VY, Akpek EK, Srinivasan M, Mascarenhas J, Massaro-Giordano G, McNamara NA, Whitcher JP, Gaynor BD. Inter-grader Agreement of the Ocular Staining Score in the Sjögren’s International Clinical Collaborative Alliance (SICCA) Registry. Am J Ophthalmol. 2015 Dec; 160(6):1150-1153.e3. PMID: 26302236. PMCID: PMC4651820

Stephens DN, McNamara NA. Altered Mucin and Glycoprotein Expression in Dry Eye Disease. Optom Vis Sci. 2015 Sep; 92(9):931-8. PMID: 26267059

Moy A, McNamara NA, Lin MC. Effects of Isotretinoin on Meibomian Glands. Optom Vis Sci. 2015 Sep; 92(9):925-30. *Shared senior authorship PMID: 26154692

McNamara NA, Ge S, Lee SM, Enghauser AM, Kuehl L, Chen FY, Gallup M, McKown RL. Reduced levels of lacritin are associated with corneal neuropathy in patients with the ocular component of Sjögren’s syndrome. Invest Ophthalmol Vis Sci. 2016 Oct 1; 57(13):5237-5243. PMID: 27711909. PMCID: PMC5063056

Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara NA. Cigarette smoke mediates nuclear to cytoplasmic trafficking of transcriptional inhibitor Kaiso through MUC1 and p120-catenin. Am J Pathol. 2016 Oct 17. PMID: 27765636. PMID: PMC5225293

Vaishnav YJ, Rucker SA, Saharia K, McNamara NA. Rapid, automated mosaicking of the human corneal subbasal plexus. Biomed Tech (Berl). 2017 Mar 4. PMID: 28258973

Farmer DT, Finley JK, Chen FY, Tarifeno-Saldivia E, McNamara NA, Knox SM, McManus, MT. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 Jul 1;427(1):12-20. PMID: 28511845

Belmonte C, Nichols JJ, Cox SM, Brock JA, Begley CG, Bereiter DA, Dartt DA, Galor A, Hamrah P, Ivanusic JJ, Jacobs DS, McNamara NA, Rosenblatt MI, Stapleton F, Wolffsohn JS. TFOS DEWS II pain and sensation report. Ocul Surf. 2017 Jul;15(3):404-437. PMID: 287363339

Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjogren’s syndrome. PLoS One. 2017 Sep 19;12(9):e0184916. eCollection 2017. PMID: 28926640

Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA. Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent. Am J Pathol. 2014 Jun; 184(6):1695-705.

Zhou D, McNamara NA. Macrophages: important players in primary Sjögren’s syndrome? Expert Rev Clin Immunol. 2014 Apr; 10(4):513-20.

Robertson DM, Alexander LJ, Bonanno JA, Fleiszig SM, McNamara N. Cornea and ocular surface disease: application of cutting-edge optometric research. Optom Vis Sci. 2014 Apr; 91(4 Suppl 1):S3-S16.

Chen YT, Chen FY, Vijmasi T, Stephens DN, Gallup M, McNamara NA. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One. 2013; 8(10):e77286.

Vijmasi T, Chen FY, Chen YT, Gallup M, McNamara N. Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Mol Vis. 2013; 19:1957-65.

Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA: Cigarette Smoke Disrupts the Integrity of Airway Adherens Junctions through the Aberrant Interaction of P120-catenin with the Cytoplasmic Tail of MUC1. J Pathol, 229:74-86, 2013.

Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara NA: Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin dependent and independent pathways. Am J Pathol, 182:1986-1995, 2013.

Chen YT, Chen F, Vijmasi T, Gallup M, McNamara NA: Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLos One 2013, in press.

Vijmasi T, Chen F, Chen YT, Gallup M, McNamara NA: Topical administration of IL-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Mol Vis 2013, in press.

Zhou D, Chen YT, Chen F, Gallup M, Vijmasi T, Bahrami AF, Noble L, Rooijen N, McNamara NA: Critical involvement of macrophage infiltration in the development of Sjögren’s syndrome-associated dry eye. Am J Pathol 181:753-60, 2012.

Chen YT, Lazarev S, Bahrami AF, Noble LB, Zhou D, Yadav M, McNamara NA: Interleukin-1 receptor signaling mediates the functional interplay between autoreactive CD4+ T cells and ocular resident cells during keratinizing squamous metaplasia in Sjögren’s syndrome. Lab Invest 92:556-70, 2012.

Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA: Cigarette Smoke Disrupts the Integrity of Airway Adherens Junctions through the Aberrant Interaction of P120-catenin with the Cytoplasmic Tail of MUC1. J Pathol Jul 26, 2012 [Epub ahead of print].

Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara NA, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T: American College of Rheumatology classification criteria for Sjögren’s Syndrome: A data-driven expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance Cohort. Arthritis Care Res 64:475-87, 2012.

Daniels TE, Cox D, Shiboski CH, Schiodt M, Wu A, Lanfranchi H, Umehara H, Zhao Y, Challacombe S, Lam MY, De Souza Y, Schiodt J, Holm H, Bisio PA, Gandolfo MS, Sawaki T, Li M, Zhang W, Varghese-Jacob B, Ibsen P, Keszler A, Kurose N, Nojima T, Odell E, Criswell LA, Jordan R, Greenspan JS; Sjögren’s International Collaborative Clinical Alliance Research Groups. Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjogren’s syndrome among 1,726 registry participants. Arthritis Rheum 63:2021-30, 2011.

Chan MF, Sack RA, Quigley D, Sathe S, Vijmasi T, Holsclaw D, Strauss EC, McNamara NA: Protein array analysis of immune and angiogenic modulators in ocular cicatricial pemphigoid. Opt Vis Sci 88:1005-9, 2011.

Chen YT, Nikulina K, Lazarev S, Gallup M, McNamara NA: Interleukin-1 as a phenotypic immuno-modulator in keratinizing squamous metaplasia of the ocular surface in Sjögren’s syndrome. Am J Pathol 177:1333-43, 2010. PMID: 20696775.

Chen YT, Gallup M, Nikulina K, Zlock L, Finkbeiner W, McNamara NA: Cigarette smoke causes EGFR-mediated depolarization of apical MUC1-mucin and junctional b-catenin in the human airway epithelium. Am J Pathol 177:1255-64, 2010. PMID: 20651243.

Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara NA, Greenspan J, Daniels TE: A simplified quantitative method of assessing keratoconjunctivitis sicca from the Sjogren’s Syndrome International Registry. Am J Ophthalmol 149:405-15, 2010.

Li S, Gallup N, Chen Y-T, McNamara NA: Molecular mechanisms of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci 51:2466-75, 2010.

Liu H, Begley CG, Chen M, Bradley A, Bonanno JA, McNamara N, Nelson JD, Simpson T: A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci 50:3671-9, 2009.

Chen YT, Li S, Nikulina K, Porco T, McNamara NA: Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis 15:563-576, 2009.

Sack R, Sathe S, Beaton AR, McNamara N, Fleiszig S, Ni M. Protein array characterization of bioactive proteins secreted by immortalized human corneal epithelium in response to pseudomonas constituents. Curr Eye Res: 34:92-8, 2009.

Li S, Nikulina K, DeVoss J, Wu A, Strauss EC, Anderson MS, McNamara NA: Small protein rich-protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci 49:34-41, 2008.

Li S, Sack R, Vijmasi T, Sathe S, Beaton A, Quigley D, Gallup M, McNamara NA: Antibody protein array analysis of the tear film cytokines. Optom Vis Sci 85:653-60, 2008.

Sack RA, Conradi L, Beaton A, Sathe S, McNamara N, Leonardi A: Antibody array characterization of inflammatory mediators in the allergic and normal tears in the open and closed eye environments. Exp Eye Res, 85:528-38, 2007.

Maltseva I, Fleiszig SM, Evans DJ, Kerr S, Sidhu SS, McNamara NA, Basbaum CB: Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp Eye Res, 85:42-53, 2007.

McNamara N, Gallup M, Sucher A, Maltseva I, McKemy D, Basbaum C: AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol, 34:653-660, 2006.

Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N: EMT in lung cancer: Is tobacco the “smoking gun”? Am J Respir Cell Mol Biol, 35:3-9, 2006.

McNamara NA, Andika R, Kwong M, Sack RA, Fleiszig SM: Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res 7:517-525, 2005.

McNamara N, Gallup M, Khong A, Maltseva I, Fahy J, Dolganov G, Basbaum C: Adenosine upregulation of the mucin gene, MUC2, in asthma. FASEB J 18:1770-2, 2004.

McNamara N: Innate Defense of the Ocular Surface. Eye Contact Lens 29: S10-13, 2003.

McNamara N, Basbaum C: Signaling networks controlling mucin production in response to gram-positive and gram-negative bacteria. Glycoconj J 18: 715-722, 2001.

McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C: ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. PNAS 98:9086-9091, 2001.

Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara NA, Lemjabbar H, Basbaum C, and Relman DA: The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter defensive strategies. PNAS 97:13847-13852, 2000.

Book Section

McNamara N, Sack R, Fleiszig SMJ: Mucin-Bacterial Binding Assays. Chapter 35. T. Corfield, ed. Glycoprotein Methods and Protocols, Methods in Molecular Biology. Humana Press, Totowa, NJ, 125:429-437, 1999.